WELLBUTRIN SR tablets should be swallowed whole and not crushed, divided, or chewed. WELLBUTRIN SR may be taken with or without food. Dilantin phenytoin sodium US prescribing information. Pfizer, Inc. What are complications of depression? afav.info terazosin
Swallow Wellbutrin SR tablets whole. So please think about this and maybe switch to the pills made by Sanzoz. This list is not complete and many other drugs can interact with bupropion. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
There are reports of arthralgia, myalgia, fever with rash and other serum sickness-like symptoms suggestive of delayed hypersensitivity. Cimetidine: The threohydrobupropion metabolite of bupropion does not appear to be produced by cytochrome P450 enzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of bupropion and its active metabolites were studied in 24 healthy young male volunteers. Following oral administration of bupropion 300 mg with and without cimetidine 800 mg, the pharmacokinetics of bupropion and hydroxybupropion were unaffected. However, there were 16% and 32% increases in the AUC and C max, respectively, of the combined moieties of threohydrobupropion and erythrohydrobupropion.
What is the most important information I should know about bupropion? SR can increase your chance of having a seizure. Bupropion can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. Tell your healthcare provider if you plan to use nicotine patches. Your healthcare provider should check your blood pressure regularly if you use nicotine patches with Wellbutrin XL to help you quit smoking.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Do not take decongestants eg, pseudoephedrine stimulants, or diet pills while you are taking Wellbutrin without first checking with your doctor. They may increase your risk of seizures. Adverse reactions that occurred in at least 5% of patients treated with bupropion HCl sustained-release 300 mg and 400 mg per day and at a rate at least twice the placebo rate are listed below. Tell your healthcare provider right away about any side effects that bother you. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. This medication should not be used if you are suddenly stopping regular use of sedatives including benzodiazepines such as drugs used to treat seizures, or alcohol. Doing so may increase your risk of seizures. This section of the Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. In some cases, a patient already receiving therapy with WELLBUTRIN SR may require urgent treatment with linezolid or intravenous methylene blue. If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of hypertensive reactions in a particular patient, WELLBUTRIN SR should be stopped promptly, and linezolid or intravenous methylene blue can be administered. The patient should be monitored for 2 weeks or until 24 hours after the last dose of linezolid or intravenous methylene blue, whichever comes first. Therapy with WELLBUTRIN SR may be resumed 24 hours after the last dose of linezolid or intravenous methylene blue. HCl sustained-release. There was a dose-related decrease in body weight. AUC and C max by 57%. The AUC and C max of hydroxybupropion metabolite were decreased by 50% and 31%, respectively. What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions? Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. Arthralgia, myalgia, and fever with rash and other symptoms suggestive of delayed hypersensitivity. Bupropion and its metabolites are present in human milk. In a lactation study of ten women, levels of orally dosed bupropion and its active metabolites were measured in expressed milk. At steady state, peak plasma concentration of hydroxybupropion occurred approximately 7 hours after administration of Wellbutrin XL, and it was approximately 7 times the peak level of the parent drug.
Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. If you have stomach upset, you may take this medication with or after a meal or snack. Taking this medication late in the day may cause trouble sleeping insomnia. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Wellbutrin SR is intended for oral use only. The inhalation of crushed tablets or injection of dissolved bupropion has been reported. You should not take bupropion if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking. What happens if I miss a dose? Wellbutrin may be taken with or without food. In the SAD trials, 82% of patients were treated with 300 mg per day, and 18% were treated with 150 mg per day. The mean daily dose was 270 mg per day. The mean duration of bupropion exposure was 126 days. SR unless your healthcare provider has told you it is okay. This section of the Medication Guide is only about the risk of changes in thinking and behavior, depression and suicidal thoughts or actions with drugs used to quit smoking. Complete atrioventricular block, extrasystoles, hypotension, hypertension in some cases severe phlebitis, and pulmonary embolism. Store Wellbutrin at room temperature, between 59 and 86 degrees F 15 and 30 degrees C in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Wellbutrin out of the reach of children and away from pets. SR and call your healthcare provider right away if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction. This drug may make you dizzy or affect your coordination. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. Alcohol can also increase your risk of dizziness or seizures. Wellbutrin. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin with or without fever; red or irritated eyes; or sores in your mouth, throat, nose, or eyes. By: Valeant Pharmaceuticals International, Inc. WELLBUTRIN XL, go to www. zebeta
Take your doses of Wellbutrin XL at least 8 hours apart. SR. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about Wellbutrin SR that is written for healthcare professionals. GAINED weight - basically I guess it is my body going into starvation mode and shutting down my metabolism - ALOT of weight I went from 160 lbs, I am 5 ft 9, to 210 lbs. This medication should not be used if you are suddenly stopping regular use of sedatives including benzodiazepines such as lorazepam drugs used to treat seizures, or alcohol. Doing so may increase your risk of seizures. The black-box warning notes the need to monitor patients taking antidepressants for signs of any worsening of their depression, and for the emergence of suicidal thoughts, especially in the first few months of treatment or when the dose is either increased or decreased. This may not be a complete list of all interactions that may occur. Ask your health care provider if Wellbutrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Tell your doctor right away if you have any of these symptoms after stopping treatment. SR and call your healthcare provider right away if you, your family, or caregiver notice any of these symptoms. SR is not a treatment for quitting smoking, it contains the same active ingredient bupropion hydrochloride as ZYBAN which is used to help patients quit smoking.
If you miss a dose, do not take an extra dose to make up for the dose you missed. Wait and take your next dose at the regular time. This is very important. Too much Wellbutrin XL can increase your chance of having a seizure. Read the Medication Guide provided by your pharmacist before you start using bupropion and each time you get a refill. If you have any questions, ask your doctor or pharmacist. For Trial 1, it refers to the mean score at the endpoint visit; for Trials 2 and 3, it refers to the mean change from baseline to the endpoint visit. What are the side effects of bupropion? Bupropion, levodopa, and amantadine have dopamine agonist effects. CNS toxicity has been reported when bupropion was coadministered with levodopa or amantadine. Adverse reactions have included restlessness, agitation, tremor, ataxia, gait disturbance, vertigo, and dizziness. It is presumed that the toxicity results from cumulative dopamine agonist effects. Use caution when administering Wellbutrin XL concomitantly with these drugs. The dose should not exceed 300 mg once daily. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Trials 1, 2 and 3, respectively. SD: standard deviation; SE: standard error; LS Mean: least-squares mean; CI: unadjusted confidence interval included for doses that were demonstrated to be effective; NA: not available. Such monitoring should include daily observation by families and caregivers. Efavirenz: In a study of healthy volunteers, efavirenz 600 mg once daily for 2 weeks reduced the AUC and C max of bupropion by approximately 55% and 34%, respectively. The AUC of hydroxybupropion was unchanged, whereas C max of hydroxybupropion was increased by 50%. Keep Wellbutrin XL and all medicines out of the reach of children. Here are some of the side effects of Wellbutrin. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have a seizure convulsions or fast, uneven heartbeats. Less serious side effects may be more likely to occur, such as: headache or migraine, nausea, vomiting, constipation, dry mouth, confusion, dizziness, tremors shaking appetite changes, weight loss or gain, mild itching or skin rash, increased sweating; or loss of interest in sex. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effects. It is important to consult with your physician or healthcare provider about any specific questions regarding your medical conditions or medications; particularly before taking any action. depakote price in malaysia
The extent of protein binding of the hydroxybupropion metabolite is similar to that for bupropion; whereas, the extent of protein binding of the threohydrobupropion metabolite is about half that seen with bupropion. Abnormal ejaculation, cystitis, dyspareunia, dysuria, gynecomastia, menopause, painful erection, salpingitis, urinary incontinence, urinary retention, and vaginitis. When switching patients from WELLBUTRIN Tablets to Wellbutrin XL or from WELLBUTRIN SR Sustained-Release Tablets to Wellbutrin XL, give the same total daily dose when possible. Citalopram: Although citalopram is not primarily metabolized by CYP2D6, in one study bupropion increased the C max and AUC of citalopram by 30% and 40%, respectively. MAOI such as linezolid or intravenous methylene blue. CGI-Improvement Scale CGI-I score. If you have a seizure while taking Wellbutrin XL, stop taking the tablets and call your healthcare provider right away. Do not take Wellbutrin XL again if you have a seizure. Wellbutrin SR is not approved for smoking cessation treatment; however, it contains the same active ingredient as the smoking cessation medication ZYBAN. Serious neuropsychiatric adverse events have been reported in patients taking bupropion for smoking cessation. Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first. XL unless directed to do so by your healthcare provider. In addition, pooled analysis of bupropion pharmacokinetic data from 90 healthy male and 90 healthy female volunteers revealed no sex-related differences in the peak plasma concentrations of bupropion. The mean systemic exposure AUC was approximately 13% higher in male volunteers compared to female volunteers. Cmax and AUC values of hydroxybupropion by 32% and 24%, respectively. What is bupropion, and how does it work mechanism of action?
SR needed for maintenance treatment is identical to the dose that provided an initial response. Periodically reassess the need for maintenance treatment and the appropriate dose for such treatment. What is a depressive disorder? I've used this cream I have in the past with no ill-effect, but after having been on welb for a month or so, low dosage, I broke out all over in hives; interestingly, except for the two patches of skin I had applied it to. I was wearing an ace bandage on my knee and the pressure from that made them especially bad on that leg; blisters formed around the bandage, one of which was about in inch high and an inch in diameter! Smokers: The effects of cigarette smoking on the pharmacokinetics of bupropion were studied in 34 healthy male and female volunteers; 17 were chronic cigarette smokers and 17 were nonsmokers. Advise patients that Wellbutrin SR is present in human milk in small amounts. Do not stop taking this medication without consulting your doctor. Your dose may need to be gradually decreased. OMG, the same thing has been happening to me since i got the green pills! SR unless directed to do so by your healthcare provider. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically more depressed, or have thoughts about suicide or hurting yourself. Older adults may be more sensitive to the side effects of this drug, especially dizziness and memory loss. Dizziness can increase the risk of falling. Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction. Avoid taking MAO inhibitors isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication. Medication Guide and assist them in understanding its contents. AUC and the C max of bupropion by 66% and 62%, respectively. The exposure of the hydroxybupropion metabolite was decreased by 78%, the threohydrobupropion decreased by 50%, and the erythrohydrobupropion decreased by 68%. Generic drugs provide Americans with lower-cost alternatives to the escalating costs of brand name drugs. These include reactions that occurred in either the 300 mg or 400 mg group at an incidence of 1% or more and were more frequent than in the placebo group. rosuvastatin cost assistance
Bupropion is a racemic mixture. The pharmacologic activity and pharmacokinetics of the individual enantiomers have not been studied. What is in the future for depression? Child-Pugh score: 7 to 15 the maximum dose is 150 mg every other day. SR again if you have a seizure. WELLBUTRIN XL is used concomitantly with MAOIs. The following adverse reactions have been identified during post-approval use of Wellbutrin SR and are not described elsewhere in the label. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Call your healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication. SR, bupropion, or to any of the inactive ingredients. Inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Wellbutrin XL and counsel them in its appropriate use.
Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Urogenital: Infrequent were impotence, polyuria, and prostate disorder. AUC at steady state is about 13 times that of bupropion. The times to peak concentrations for the erythrohydrobupropion and threohydrobupropion metabolites are similar to that of hydroxybupropion. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Check your pressure regularly and tell your doctor if the results are high. Is bupropion available as a generic drug? It is generally agreed that acute episodes of depression require several months or longer of antidepressant drug treatment beyond the response in the acute episode. There are no controlled trials assessing the safety of bupropion in patients with a recent history of myocardial infarction or unstable cardiac disease. All medicines may cause side effects, but many people have no, or minor, side effects. AUC and C max of bupropion by 22% and 21%, respectively. The exposure of the hydroxybupropion metabolite was decreased by 23%, the threohydrobupropion decreased by 38%, and the erythrohydrobupropion decreased by 48%. SR may impair their ability to perform tasks requiring judgment or motor and cognitive skills. astelin
If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy. Nerves, in a process referred to as reuptake, may recycle released neurotransmitters. Special Senses: Infrequent were accommodation abnormality and dry eye. AUC for subjects with end-stage renal failure. Bupropion is used to treat depression. It can improve your mood and feelings of well-being. It may work by helping to restore the balance of certain natural chemicals neurotransmitters in your brain. What happens if I overdose? Wellbutrin is the brand name for bupropion, a prescription drug that's used to treat depression. Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine and does not inhibit monoamine oxidase or the reuptake of serotonin. If you are using bupropion to quit smoking and experience any of these symptoms, stop taking it and contact your doctor right away. Also, tell your doctor right away if you have any of these symptoms after stopping treatment with bupropion. Do not take more or less medication or take it more frequently than prescribed. Taking more than the recommended dose of bupropion may increase your risk of having a seizure. Do not take more than 150 milligrams as a single dose, and do not take more than 450 milligrams per day.
In vitro, bupropion and hydroxybupropion are CYP2D6 inhibitors. Wellbutrin XL should be used with a patient support program. It is important to participate in the behavioral program, counseling, or other support program your healthcare professional recommends. In vitro findings suggest that CYP2B6 is the principal isoenzyme involved in the formation of hydroxybupropion, while cytochrome P450 enzymes are not involved in the formation of threohydrobupropion. Where can I get more information? The risk of administering methylene blue by non-intravenous routes such as oral tablets or by local injection or in intravenous doses much lower than 1 mg per kg with WELLBUTRIN SR is unclear. If upset occurs, you may take this drug with food. Never stop an antidepressant medicine without first talking to a healthcare provider. Stopping an antidepressant medicine suddenly can cause other symptoms. Wellbutrin XL is indicated for the prevention of seasonal major depressive episodes in patients with a diagnosis of seasonal affective disorder SAD. Bupropion produced a positive response 2 to 3 times control mutation rate in 2 of 5 strains in one Ames bacterial mutagenicity assay, but was negative in another. Bupropion produced an increase in chromosomal aberrations in 1 of 3 in vivo rat bone marrow cytogenetic studies. Food and Drug Administration by visiting www. Slone Epidemiology case control study did not find increased risk for LVOTO. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Although Wellbutrin SR is not indicated for smoking cessation treatment, it contains the same active ingredient as ZYBAN which is approved for this use. Inform patients that some patients have experienced changes in mood including depression and mania psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation and suicide when attempting to quit smoking while taking bupropion. Ticlopidine and Clopidogrel: Concomitant treatment with these drugs can increase bupropion exposure but decrease hydroxybupropion exposure. SR. It is important for you to follow-up with your healthcare provider until your symptoms go away. WELLBUTRIN XL treatment may lead to decreased alcohol tolerance. buy now generic motilium shop
Bupropion hydrochloride extended-release tablets are intended for oral use only. The inhalation of crushed tablets or injection of dissolved bupropion has been reported. The FDA approved bupropion in December 1985. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Lamotrigine: Multiple oral doses of bupropion had no statistically significant effects on the single-dose pharmacokinetics of lamotrigine in 12 healthy volunteers. WELLBUTRIN should be considered. You may take Wellbutrin SR with or without food. IMPORTANT: Be sure to read the three sections of this Medication Guide. Don't drive or operate dangerous machinery until you know how the medication affects you. When used concomitantly with Wellbutrin SR, it may be necessary to decrease the dose of these CYP2D6 substrates, particularly for drugs with a narrow therapeutic index. Ticlopidine and Clopidogrel: In a study in healthy male volunteers, clopidogrel 75 mg once daily or ticlopidine 250 mg twice daily increased exposures C max and AUC of bupropion by 40% and 60% for clopidogrel, by 38% and 85% for ticlopidine, respectively. The exposures of hydroxybupropion were decreased. NTS, and placebo, respectively. The majority of these subjects had evidence of pre-existing hypertension. Many drugs can interact with bupropion. Not all possible interactions are listed here. XL unless your healthcare provider has told you it is okay.
HCl immediate-release in the range of 300 mg to 450 mg per day. The risk of seizure can be reduced if the Wellbutrin XL dose does not exceed 450 mg once daily and the titration rate is gradual. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment. Store at room temperature away from light and moisture. You may notice an odor from the tablets; this is normal and does not affect how they work. not store in the bathroom. Keep all away from children and pets. Do not take any other medicines while taking Wellbutrin XL unless your healthcare provider has told you it is okay. SR tablets should be swallowed whole and not crushed, divided, or chewed. Wellbutrin SR may be taken with or without food. I've made an appointment with my ONGYN for next Tuesday and I am going to ask to be put on Wellbutrion with the hopes that it can level me out. Your post really struck a nerve with me and I felt compelled to respond to you post because I understand exactly what you're dealing with and if you ever need to chat then let me know and I'll leave you my email address. How should I take Wellbutrin XL bupropion? What else do I need to know about antidepressant medicines? Check with your pharmacist about how to dispose of unused medicine. iressa order online pharmacy canada
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NTS, and placebo, respectively. The efficacy of the immediate-release formulation of bupropion was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult patients with MDD. MDD and other psychiatric disorders. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction with antidepressants compared to placebo in adults aged 65 and older. The risk may be lowered if the dosage is not suddenly increased. The most common side effects of Celexa citalopram are nausea, diarrhea, vomiting, stomach pain, drowsiness, excessive tiredness, uncontrollable shaking of a part of the body, excitement, nervousness, muscle or joint pain, dry mouth, excessive sweating, changes in sex drive or ability, and loss of appetite. Some side effects can be serious. If you experience any of the following symptoms call your doctor immediately: seeing things or hearing voices that do not exist, fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness, or seizures. Loss of effect of antidepressant therapy appears to occur with most or all antidepressants. Causes of relapse are mostly unknown, with the exception of treatment non-compliance, and may relate to disease factors, pharmacologic effects, or a combination of these factors. Be sure to seek the advice of a qualified medical or mental health professional before making any changes in your medication regimen.
Zyban bupropion hydrochloride US prescribing information. If you take a urine drug screening test, Wellbutrin SR may make the test result positive for amphetamines. If you tell the person giving you the drug screening test that you are taking Wellbutrin SR, they can do a more specific drug screening test that should not have this problem. The second trial demonstrated no statistically significant differences in the pharmacokinetics of bupropion and its active metabolites in 9 subjects with mild to moderate hepatic cirrhosis compared to 8 healthy volunteers. However, more variability was observed in some of the pharmacokinetic parameters for bupropion AUC, C max, and T max and its active metabolites t ½ in subjects with mild to moderate hepatic cirrhosis. In addition, in patients with severe hepatic cirrhosis, the bupropion C max and AUC were substantially increased mean difference: by approximately 70% and 3-fold, respectively and more variable when compared to values in healthy volunteers; the mean bupropion half-life was also longer 29 hours in subjects with severe hepatic cirrhosis vs. 19 hours in healthy subjects. For the metabolite hydroxybupropion, the mean C max was approximately 69% lower. For the combined amino-alcohol isomers threohydrobupropion and erythrohydrobupropion, the mean C max was approximately 31% lower.
This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. Alcohol can increase your risk of or seizures. Reactions have been characterized by pruritus, urticaria, angioedema, and dyspnea requiring medical treatment. Following single oral administration of Wellbutrin XL tablets to healthy volunteers, the median time to peak plasma concentrations for bupropion was approximately 5 hours. The presence of food did not affect the peak concentration or area under the curve of bupropion.
Educate patients that Wellbutrin XL contains the same active ingredient bupropion found in ZYBAN, which is used as an aid to smoking cessation treatment, and that Wellbutrin XL should not be used in combination with ZYBAN or any other medications that contain bupropion hydrochloride such as WELLBUTRIN SR, the sustained-release formulation, WELLBUTRIN, the immediate-release formulation, and APLENZIN, a bupropion hydrobromide formulation. In addition, there are a number of generic bupropion HCl products for the immediate, sustained, and extended-release formulations. MDD and other psychiatric disorders.